2021/05/15 更新

写真a

ミウラ コウヘイ
三浦 宏平
MIURA Kouhei
所属
医歯学総合病院 消化器外科 助教
職名
助教

学位

  • 博士(医学) ( 2015年3月   新潟大学 )

研究分野

  • ライフサイエンス / 消化器外科学  / 移植

経歴(researchmap)

  • 新潟大学医歯学総合研究科   小児外科学分野   助教

    2017年4月 - 現在

  • 熊本大学医学部付属病院   小児外科・移植外科学分野   助教

    2016年4月 - 2017年3月

  • 新潟大学医歯学総合研究科   高次救命災害治療センター   助教

    2014年4月 - 2016年3月

  • 新潟大学医歯学総合研究科   消化器・一般外科学分野   医員

    2011年10月 - 2012年3月

  • 厚生連刈羽郡総合病院   外科   医員

    2011年4月 - 2011年9月

  • 新潟大学医歯学総合研究科   消化器・一般外科学分野   医員

    2010年10月 - 2011年3月

  • 鶴岡市立荘内病院   外科   医員

    2009年10月 - 2010年9月

  • 新潟大学医歯学総合研究科   消化器・一般外科学分野   医員

    2008年10月 - 2009年9月

  • 新潟県立新発田病院   外科   医員

    2008年4月 - 2008年9月

  • 新潟県立新発田病院   初期臨床研修医

    2006年4月 - 2008年3月

▶ 全件表示

経歴

  • 新潟大学   医歯学総合病院 消化器外科   助教

    2021年4月 - 現在

  • 新潟大学   医歯学総合病院 高次救命災害治療センター   助教

    2020年4月 - 2021年3月

  • 新潟大学   医歯学総合研究科 生体機能調節医学専攻 機能再建医学   助教

    2017年10月 - 2020年3月

  • 新潟大学   医歯学総合病院 小児外科   助教

    2017年4月 - 2017年9月

  • 新潟大学   医歯学総合病院 消化器外科   特任助教

    2016年4月 - 2017年3月

  • 新潟大学   医歯学総合病院 高次救命災害治療センター   助教

    2014年4月 - 2016年3月

▶ 全件表示

学歴

  • 新潟大学   大学院医歯学総合研究科   博士課程

    2012年4月 - 2015年3月

  • 鹿児島大学

    2012年4月 - 2014年3月

  • 新潟大学   医学部   医学科

    2000年4月 - 2006年3月

所属学協会

  • 日本肝胆膵外科学会

  • 日本移植学会

  • 日本消化器病学会

  • 日本消化器外科学会

  • 日本外科学会

  • 日本胆道学会

  • 日本小児外科学会

  • 日本内視鏡外科学会

  • 日本臨床外科学会

  • 日本救急医学会

  • 日本膵臓学会

▶ 全件表示

 

論文

  • Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma. 査読

    Wakai T, Sakata J, Katada T, Hirose Y, Soma D, Prasoon P, Miura K, Kobayashi T

    Annals of gastroenterological surgery2 ( 5 ) 359 - 366   2018年9月

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  • Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis. 査読

    Hirose Y, Nagahashi M, Katsuta E, Yuza K, Miura K, Sakata J, Kobayashi T, Ichikawa H, Shimada Y, Kameyama H, McDonald KA, Takabe K, Wakai T

    Scientific reports8 ( 1 ) 10814   2018年7月

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  • Adult living donor liver transplantation for patients with portal vein thrombosis: A single-center experience 査読

    Kohei Miura, Yasuhiko Sugawara, Koushi Uchida, Seiichi Kawabata, Daiki Yoshii, Kaori Isono, Shintaro Hayashida, Yuki Ohya, Hidekazu Yamamoto, Takashi Kobayashi, Toshifumi Wakai, Yukihiro Inomata, Taizo Hibi

    Transplantation Direct4 ( 5 ) e341   2018年5月

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    掲載種別:研究論文(学術雑誌)  

    Copyright © 2018 The Author(s). Background. Living donor liver transplantation (LDLT) for patients with portal vein thrombosis (PVT) is associated with several technical challenges for its complicated procedures and poor outcomes. Some institutions still consider preexisting PVT as a relatively contraindication for LDLT. Methods. Between April 2010 and May 2016, 129 adults underwent LDLT at our institution, and 28 (21.7%) of whom had preexisting PVT. Portal vein thrombosis was diagnosed using preoperative imaging techniques and intraoperative findings. The characteristics and outcomes of the cases were retrospectively evaluated. Results. The type of PVT included Yerdel grade 1 in 21 (75.0%) cases, grade 2 in 3 (10.7%) cases, and grade 3 in 4 (14.3%) cases. There were no cases of Yerdel grade 4 PVT. After removing thrombus inside the vessel, we performed simple portal vein anastomosis in 25 (89.3%) cases, patch technique with vascular graft in 1 case (3.6%), and an interposition technique with vascular graft in 2 cases (7.1%). Compared with the non-PVT group, cold ischemic time was longer (P = 0.012) and the rate of postoperative PVT was higher (P = 0.001) in PVT group. In the comparison between the recipient without and with postoperative PVT, the existence of preoperative PVT was the independent risk factor in the multivariate analysis (hazard ratio, 7.511; 95% confidence interval 1.382-40.820; P = 0.020). Conclusions. Although it had a technically complicated operation, LDLT could be safely performed in the patients with PVT in our institution.

    DOI: 10.1097/TXD.0000000000000780

    Scopus

    PubMed

  • Small bowel obstruction after ileal pouch-anal anastomosis with a loop ileostomy in patients with ulcerative colitis 査読

    Hitoshi Kameyama, Yoshifumi Hashimoto, Yoshifumi Shimada, Saki Yamada, Ryoma Yagi, Yosuke Tajima, Takuma Okamura, Masato Nakano, Kohei Miura, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Shin-Ichi Kosugi, Toshifumi Wakai

    Annals of Coloproctology34 ( 2 ) 94 - 100   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Korean Society of Coloproctology  

    Purpose: Small bowel obstruction (SBO) remains a common complication after pelvic or abdominal surgery. However, the risk factors for SBO in ulcerative colitis (UC) surgery are not well known. The aim of the present study was to clarify the risk factors associated with SBO after ileal pouch-anal anastomosis (IPAA) with a loop ileostomy for patients with UC. Methods: The medical records of 96 patients who underwent IPAA for UC between 1999 and 2011 were reviewed. SBO was confirmed based on the presence of clinical symptoms and radiographic findings. The patients were divided into 2 groups: the SBO group and the non-SBO group. We also analyzed the relationship between SBO and computed tomography (CT) scan image parameters. Results: The study included 49 male and 47 female patients. The median age was 35.5 years (range, 14-72 years). We performed a 2- or 3-stage procedure as a total proctocolectomy and IPAA for patients with UC. SBO in the pretakedown of the loop ileostomy after IPAA occurred in 22 patients (22.9%). Moreover, surgical intervention for SBO was required for 11 patients. In brief, closure of the loop ileostomy was performed earlier than expected. A multivariate logistic regression analysis revealed that the 2-stage procedure (odds ratio, 2.850
    95% confidence interval, 1.009-8.044
    P = 0.048) was a significant independent risk factor associated with SBO. CT scan image parameters were not significant risk factors of SBO. Conclusion: The present study suggests that a 2-stage procedure is a significant risk factor associated with SBO after IPAA in patients with UC.

    DOI: 10.3393/ac.2017.06.14

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    PubMed

  • Effects of carbon monoxide on early dysfunction and microangiopathy following GalT-KO porcine pulmonary xenotransplantation in cynomolgus monkeys 査読

    Hisashi Sahara, Mitsuhiro Sekijima, Yuichi Ariyoshi, Akihiro Kawai, Kohei Miura, Shiori Waki, Louras Nathan, Yusuke Tomita, Takehiro Iwanaga, Kazuaki Nakano, Hitomi Matsunari, Hiroshi Date, Hiroshi Nagashima, Akira Shimizu, Kazuhiko Yamada

    Xenotransplantation25 ( 1 )   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing Inc.  

    Background: Despite progress in the current genetic manipulation of donor pigs, most non-human primates were lost within a day of receiving porcine lung transplants. We previously reported that carbon monoxide (CO) treatment improved pulmonary function in an allogeneic lung transplant (LTx) model using miniature swine. In this study, we evaluated whether the perioperative treatment with low-dose inhalation of CO has beneficial effects on porcine lung xenografts in cynomolgus monkeys (cynos). Methods: Eight cynos received orthotopic left LTx using either α-1,3-galactosyltransferase knockout (GalT-KO
    n = 2) or GalT-KO with human decay accelerating factor (hDAF) (GalT-KO/hDAF
    n = 6) swine donors. These eight animals were divided into three groups. In Group 1 (n = 2), neither donor nor recipients received CO therapy. In Group 2 (n = 4), donors were treated with inhaled CO for 180-minute. In Group 3 (n = 2), both donors and recipients were treated with CO (donor: 180-minute
    recipient: 360-minute). Concentration of inhaled CO was adjusted based on measured levels of carboxyhemoglobin in the blood (15%-20%). Results: Two recipients survived for 3 days
    75 hours (no-CO) and 80 hours (CO in both the donor and the recipient), respectively. Histology showed less inflammatory cell infiltrates, intravascular thrombi, and hemorrhage in the 80-hour survivor with the CO treatment than the 75-hours non-CO treatment. Anti–non-Gal cytotoxicity levels did not affect the early loss of the grafts. Although CO treatment did not prolong overall xeno lung graft survival, the recipient/donor CO treatment helped to maintain platelet counts and inhibit TNF-α and IL-6 secretion at 2 hours after revascularization of grafts. In addition, lung xenografts that were received recipient/donor CO therapy demonstrated fewer macrophage and neutrophil infiltrates. Infiltrating macrophages as well as alveolar epithelial cells in the CO-treated graft expressed heme oxygenase-1. Conclusion: Although further investigation is required, CO treatment may provide a beneficial strategy for pulmonary xenografts.

    DOI: 10.1111/xen.12359

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    PubMed

  • Feasibility of Monotherapy by Rituximab Without Additional Desensitization in ABO-incompatible Living-Donor Liver Transplantation 査読

    Hidekazu Yamamoto, Koshi Uchida, Seiichi Kawabata, Kaori Isono, Kohei Miura, Shintaro Hayashida, Yuki Oya, Yasuhiko Sugawara, Yukihiro Inomata

    Transplantation102 ( 1 ) 97 - 104   2018年1月

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    掲載種別:研究論文(学術雑誌)  

    Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Background Rituximab is a cornerstone in the regimens of desensitization for ABO-incompatible living-donor liver transplantation (ABO-i LDLT) that makes this modality an acceptable option for liver transplantation. Plasmapheresis (PP) to reduce anti-ABO antibody titer and local infusion (LI) therapy were practiced as the strategies for desensitization before the application of rituximab and were reported as additional treatments. The aim of this study was to clarify the feasibility of monotherapy by rituximab without any additional desensitization treatments in ABO-i LT. Methods Forty patients receiving ABO-i LDLT with rituximab were enrolled in this retrospective study. The patients were divided into 2 groups: the rituximab with pretransplant PP and posttransplant LI (RPL) group (n = 20) and the rituximab monotherapy (RM) without any additional treatment group (n = 20). The groups were then compared in terms of the rates of patient survival, antibody-mediated rejection (AMR), and infection. Results The 1-, 3-, and 5-year patient survival rates were 85%, 85%, and 85% in the RPL group and 89%, 80%, and 80% in the RM group, respectively. There was no significant difference in patient survival between the 2 groups. There were no episodes of AMR in either group. The RM group had a lower rate of fungal and viral infections than the RPL group. Conclusions Pretransplant rituximab without additional treatments yielded satisfactory outcomes comparable to that with additional treatments, such as PP and LI.

    DOI: 10.1097/TP.0000000000001956

    Scopus

    PubMed

  • Six National University Consortium in Liver Transplant Professionals Training (SNUC-LT) Program in Japan 査読

    K. Takagi, K. Miura, S. Nakanuma, S. Sakamoto, H. Yamamoto, T. Yagi, S. Eguchi, T. Ohta, T. Wakai, M. Ohtsuka, S. Uemoto, M. Kasahara, Y. Inomata

    Transplantation Proceedings50 ( 1 ) 168 - 174   2018年

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    掲載種別:研究論文(学術雑誌)  

    © 2017 Elsevier Inc. Background: There has been no public structured training program for transplant surgeons in Japan. However, such a program is crucial for optimizing liver transplant surgery and training young professionals in liver transplant surgery. A comprehensive training program was recently developed and the underlying concepts, structure and curriculum, and results of this program are described here. Methods: We developed a 3-year training program in 2014 called the Six National University Consortium in Liver Transplant Professionals Training (SNUC-LT) program supported by the Ministry of Education, Culture, Sports, Science, and Technology. This program is based on strong cooperation among 6 national universities (Kumamoto, Okayama, Nagasaki, Kanazawa, Niigata, and Chiba Universities). The program includes various courses to help trainees learn transplant theory and practice as well as to teach surgical skills required to safely perform transplant surgery. Results: Three trainees completed the specially designed 3-year curriculum. They attended lectures on transplant theory for an average of 59 hours and participated in an average of 44 liver transplant surgeries and 51 liver resections for transplant practice. Trainees from low-volume centers had sufficient opportunities to attend operations in high-volume centers because of the cooperative agreement among the universities. After finishing the program, the trainees were certified as talent-proven liver transplant surgeons. Conclusions: The SNUC-LT program is the first national program in Japan to have strong professional support. Our multicenter program enables young surgeons to have more abundant knowledge, more extensive experience, better surgical skills, and smoother communication skills in the field of liver transplantation.

    DOI: 10.1016/j.transproceed.2017.11.026

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  • The outcomes of pediatric liver retransplantation from a living donor: a 17-year single-center experience 査読

    Kohei Miura, Seisuke Sakamoto, Keita Shimata, Masaki Honda, Takashi Kobayashi, Toshifumi Wakai, Yasuhiko Sugawara, Yukihiro Inomata

    SURGERY TODAY47 ( 11 ) 1405 - 1414   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Liver retransplantation is the only therapeutic option for patients with graft failure after liver transplantation. The aim of this study is to evaluate the outcomes of pediatric retransplantation from living donor at a single center.
    Between December 1998 to August 2015, retransplantation from a living donor was performed for 14 children (< 18 years of age) at Kumamoto University Hospital. The characteristics of the retransplantation recipient and the clinicopathological factors between primary transplantation and retransplantation were analyzed to detect the prognostic factors.
    In retransplantation, the operative time was longer and the amount of blood loss was greater in comparison to primary transplantation. The 1-, 3-, and 5-year survival rates from the date of retransplantation were 85.7, 85.7, and 78.6%, respectively. The rates of re-laparotomy after primary transplantation, bile leakage and postoperative bleeding after retransplantation were higher than after primary transplantation. Among the three patients who died after retransplantation, the operative time, the rate of re-laparotomy after primary transplantation and the incidence of gastrointestinal complications were higher in comparison to the surviving patients.
    Pediatric retransplantation from a living donor is an acceptable procedure that could save the lives of recipients with failing allografts when organs from deceased donors are scarce. To ensure good results, it is essential to make an appropriate assessment of the cardiopulmonary function and the infectious state of the patients before Re-LDLT.

    DOI: 10.1007/s00595-017-1533-7

    Web of Science

    PubMed

  • [Mixed Type Liposarcoma with Intra-Abdominal Bleeding - Report of a Case]. 査読

    Miura Y, Sakata J, Ando T, Soma D, Yuza K, Hirose Y, Ishikawa H, Miura K, Takizawa K, Kobayashi T, Ichikawa H, Nagahashi M, Shimada Y, Kameyama H, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy44 ( 12 ) 1155 - 1157   2017年11月

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  • Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients. 査読

    Koyama Y, Moro K, Nakano M, Miura K, Nagahashi M, Kosugi SI, Tsuchida J, Ikarashi M, Nakajima M, Ichikawa H, Hanyu T, Shimada Y, Sakata J, Kameyama H, Kobayashi T, Wakai T

    Journal of clinical medicine research9 ( 10 ) 831 - 837   2017年10月

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  • Hand-assisted laparoscopic Hassab's procedure for esophagogastric varices with portal hypertension. 査読

    Kobayashi T, Miura K, Ishikawa H, Soma D, Zhang Z, Ando T, Yuza K, Hirose Y, Katada T, Takizawa K, Nagahashi M, Sakata J, Kameyama H, Wakai T

    Surgical case reports3 ( 1 ) 111   2017年10月

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  • Outcomes of treatment with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation 査読

    Masaki Honda, Yasuhiko Sugawara, Takehisa Watanabe, Masakuni Tateyama, Motohiko Tanaka, Koushi Uchida, Seiichi Kawabata, Daiki Yoshii, Kouhei Miura, Kaori Isono, Shintaro Hayashida, Yuki Ohya, Hidekazu Yamamoto, Yutaka Sasaki, Yukihiro Inomata

    HEPATOLOGY RESEARCH47 ( 11 ) 1147 - 1154   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Aim: The development of direct-acting oral agents has dramatically changed the treatment strategy of hepatitis C virus (HCV) infection. Here we aimed to reveal the efficacy and safety of daclatasvir (DCV) and asunaprevir (ASV) for recurrent HCV genotype 1 infection after liver transplantation (LT).
    Methods: A retrospective study was undertaken on nine patients who underwent a 24-week DCV/ASV treatment regimen for recurrent HCV genotype 1 infection. Five of the patients were men; four had failed treatment with pegylated interferon (Peg-IFN)/ribavirin, two had failed simeprevir/Peg-IFN/ribavirin, one had the resistance-associated variant Y93H in the NS5A region, and one underwent maintenance dialysis.
    Results: Median time to treatment initiation following LT was 70months. Of the nine patients treated with DCV/ASV, eight (88.9%) achieved a sustained viral response 12weeks after completion of therapy (SVR12). The patient with virologic failure had failed simeprevir/Peg-interferon/ribavirin therapy 4months before undergoing the DCV/ASV treatment regimen. In addition, a resistance-associated variant D168E in the NS3 region was detected in the patient after discontinuation of the DCV/ASV regimen. The trough level of tacrolimus tended to decrease, and renal function showed no significant changes during treatment. Adverse events occurred in two patients (22.2%), but no severe adverse events occurred during treatment.
    Conclusions: The DCV/ASV regimen was well tolerated, resulting in high rates of sustained viral response 12weeks after completion of therapy for LT patients with recurrent HCV genotype 1 infection.

    DOI: 10.1111/hepr.12853

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    PubMed

  • Relevance of Dissection of the Posterior Superior Pancreaticoduodenal Lymph Nodes in Gallbladder Carcinoma 査読

    Jun Sakata, Takashi Kobayashi, Yosuke Tajima, Taku Ohashi, Yuki Hirose, Kabuto Takano, Kazuyasu Takizawa, Kohei Miura, Toshifumi Wakai

    ANNALS OF SURGICAL ONCOLOGY24 ( 9 ) 2474 - 2481   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Background. This study was designed to evaluate the prognostic value of positive posterior superior pancreaticoduodenal lymph nodes to clarify the need for dissection of these nodes.
    Methods. A total of 148 patients with gallbladder carcinoma who underwent radical resection including dissection of the posterior superior pancreaticoduodenal nodes were enrolled. The incidence of metastasis and the survival rates among patients with metastasis to each lymph node group were calculated.
    Results. Of the 148 patients, 70 (47%) had nodal disease. The incidences of metastasis in the cystic duct, pericholedochal, retroportal, and hepatic artery node groups, defined as regional nodes in the UICC TNM staging system, ranged from 8.3 to 24.3% with 5-year survival rates of 12.5-46.4% in patients with positive nodes. The incidence of metastasis to the posterior superior pancreaticoduodenal nodes was 12.8% with a 5-year survival rate of 31.6% in patients with positive nodes. Survival after resection was significantly better in patients with distant nodal disease affecting only the posterior superior pancreaticoduodenal nodes (5-year survival, 55.6%) than in patients with distant nodal disease beyond these nodes (5-year survival, 15.0%; p = 0.046), whereas survival after resection was comparable between the former group and patients with regional nodal disease alone (5-year survival, 40.7%; p = 0.426).
    Conclusions. In gallbladder carcinoma, involvement of the posterior superior pancreaticoduodenal nodes is similar to that of regional nodes in terms of both the incidence of metastasis and the impact on survival. Inclusion of the posterior superior pancreaticoduodenal nodes among the regional nodes should be considered.

    DOI: 10.1245/s10434-017-5939-7

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    PubMed

  • Low fat-containing elemental formula is effective for postoperative recovery and potentially useful for preventing chyle leak during postoperative early enteral nutrition after esophagectomy 査読

    Kazuki Moro, Yu Koyama, Shin-ichi Kosugi, Takashi Ishikawa, Hiroshi Ichikawa, Takaaki Hanyu, Kohei Miura, Masayuki Nagahashi, Masato Nakajima, Kumiko Tatsuda, Junko Tsuchida, Chie Toshikawa, Mayuko Ikarashi, Yoshifumi Shimada, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Toshifumi Wakai

    CLINICAL NUTRITION35 ( 6 ) 1423 - 1428   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CHURCHILL LIVINGSTONE  

    Background and aims: Transthoracic esophagectomy using 3-field lymphadenectomy (TTE-3FL) for esophageal cancer is one of the most aggressive gastrointestinal surgeries. Early enteral nutrition (EN) for TTE-3FL patients is useful and valid for early recovery; however, EN using a fat-containing formula risks inducing chyle leak. In the present study, we retrospectively examined esophageal cancer patients treated byTTE-3FL and administered postoperative EN to elucidate the validity of lowering the fat levels in elemental formulas to prevent postoperative chyle leak and improve postoperative recovery.
    Methods: A total of 74 patients who received TTE-3FL for esophageal cancer were retrospectively examined. Patients were classified into two groups according to the type of postoperative EN: Group LF patients received a low-fat elemental formula, and Group F patients received a standard fat-containing polymeric formula. The following clinical factors were compared between the groups: EN start day, maximum EN calories administered, duration of respirator use, length of ICU stay, incidence of postoperative infectious complications, use of parenteral nutrition (PN), and incidence of postoperative chyle leak.
    Results: Patients in Group LF were started on EN significantly earlier after surgery and they consumed significantly higher maximum EN calories compared to Group F patients (P < 0.01). Duration of respirator use and length of ICU stay were also significantly shorter, and TPN was used significantly less in Group LF compared to Group F (P < 0.05). Postoperative chyle leak was observed in six patients in total (8.1%); five patients in Group F and one patient in Group LF, although there was no significant difference in frequency of chyle leak per patient between Group LF and Group F.
    Conclusions: Early EN using low-fat elemental formula after esophagectomy with three-field lymphadenectomy was safe and valid for postoperative recovery and potentially useful in preventing chyle leak. (C) 2016 The Authors. Published by Elsevier Ltd.

    DOI: 10.1016/j.clnu.2016.03.018

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    PubMed

  • Staged laparotomies based on the damage control principle to treat hemodynamically unstable grade IV blunt hepatic injury in an eight-year-old girl. 査読

    Kobayashi T, Kubota M, Arai Y, Ohyama T, Yokota N, Miura K, Ishikawa H, Soma D, Takizawa K, Sakata J, Nagahashi M, Kameyama H, Wakai T

    Surgical case reports2 ( 1 ) 134   2016年12月

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  • [Surgical Resection for Carcinoma Arising from the Remnant Intrapancreatic Bile Duct after Excision of a Congenital Choledochal Cyst - A Case Report]. 査読

    Shimada T, Sakata J, Ando T, Yuza K, Toge K, Hirose Y, Katada T, Ishikawa H, Miura K, Ohashi T, Takizawa K, Takano K, Kobayashi T, Tomita H, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 2101 - 2102   2016年11月

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  • [A Case of Long-Term Survival after Repeated Peritoneal Recurrences of Perforated Sigmoid Colon Cancer Treated with Systemic Chemotherapy and R0 Resection of Peritoneal Tumors]. 査読

    Watanabe T, Kobayashi T, Wakai A, Yagi R, Tanaka K, Miura K, Tajima Y, Nagahashi M, Shimada Y, Sakata J, Kameyama H, Kobayashi T, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 2139 - 2141   2016年11月

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  • [Long-Term Survival after Reoperation for Lung Metastasis of Resected Pancreatic Adenocarcinoma - A Case Report]. 査読

    Ishikawa H, Takano K, Ando T, Soma D, Yuza K, Hirose Y, Katada T, Miura K, Ohashi T, Takizawa K, Nagahashi M, Sakata J, Kameyama H, Kobayashi T, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 2199 - 2201   2016年11月

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  • [A Systematic Analysis of Oncogene and Tumor Suppressor Genes for Panitumumab-Resistant Rectal Cancer with Wild RAS Gene - A Case Report]. 査読

    Tajima Y, Shimada Y, Yagi R, Okamura T, Nakano M, Kameyama H, Nogami H, Maruyama S, Takii Y, Miura K, Ichikawa H, Nagahashi M, Sakata J, Kobayashi T, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 2280 - 2282   2016年11月

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  • [A Case of Metastatic Colorectal Cancer with HER2 Overexpression/Amplification]. 査読

    Matsumoto A, Shimada Y, Yagi R, Miura K, Tajima Y, Okamura T, Nakano M, Kameyama H, Nogami H, Maruyama S, Takii Y, Ichikawa H, Sakata J, Kobayashi T, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 2307 - 2309   2016年11月

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  • [Resection for a Locally Advanced Duodenal Adenocarcinoma with Obstructive Jaundice and Hepatic and Pancreatic Invasion - A Case Report]. 査読

    Hirose Y, Sakata J, Soma D, Katada T, Ishikawa H, Miura K, Ohashi T, Takizawa K, Takano K, Kobayashi T, Kameyama H, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 2077 - 2079   2016年11月

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  • [Lymph Node Recurrence of Small Cell Carcinoma of the Extrahepatic Bile Ducts Effectively Treated with Cisplatin plus Irinotecan Chemotherapy - Report of a Case]. 査読

    Katada T, Sakata J, Ando T, Soma D, Yuza K, Toge K, Hirose Y, Ishikawa H, Miura K, Ohashi T, Takizawa K, Takano K, Kobayashi T, Kameyama H, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 2083 - 2085   2016年11月

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  • [A Case of Advanced Gastric Cancer Resected for Rebleeding after Palliative Radiotherapy for Hemostasis]. 査読

    Muneoka Y, Ichikawa H, Ishikawa T, Hanyu T, Sato Y, Kano Y, Usui K, Otani T, Hishiki M, Miura K, Nagahashi M, Sakata J, Kobayashi T, Kameyama H, Kosugi S, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 1936 - 1938   2016年11月

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  • [Surgical Resection after Gemcitabine plus Cisplatin Chemotherapy for Intrahepatic Cholangiocarcinoma with Multiple Lymph Node Metastases - Report of a Case]. 査読

    Otani T, Sakata J, Kameyama H, Otani A, Hirose Y, Tamura H, Morimoto Y, Miura K, Yoshino K, Kido T, Kobayashi T, Endo K, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 1764 - 1766   2016年11月

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  • [A Case of Metastatic Colon Cancer Dramatically Affected by Anti-EGFR Antibody Therapy]. 査読

    Yagi R, Shimada Y, Miura K, Tajima Y, Okamura T, Nakano M, Ichikawa H, Nagahashi M, Sakata J, Kobayashi T, Kameyama H, Wakai T, Nogami H, Maruyama S, Takii Y

    Gan to kagaku ryoho. Cancer & chemotherapy43 ( 12 ) 1800 - 1802   2016年11月

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  • Study of Immune Tolerance Cases in Adult Living Donor Liver Transplantation 査読

    K. Miura, T. Kobayashi, Z. Zhang, D. Soma, Y. Hirose, H. Ishikawa, K. Takizawa, M. Nagahashi, J. Sakata, H. Kameyama, M. Minagawa, S. Kosugi, Y. Koyama, T. Wakai

    TRANSPLANTATION PROCEEDINGS48 ( 4 ) 1119 - 1122   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Background. Complete immune tolerance is the chief goal in organ transplantation. This study aimed to evaluate patients who successfully withdrew from immunosuppressive (IS) agents after living donor liver transplantation (LDLT).
    Materials and Methods. A retrospective review of all adult LDLT from July 1999 to March 2012 was conducted. In patients who acquired immune tolerance after LDLT, their background and the course of surgical procedures were evaluated.
    Results. Of a total of 101 adult LDLT patients, 8 patients were completely free of IS agents. Six of these patients (75%) were female, and the median age at the time of transplantation was 56 years (range, 31-66 years). The primary disease causing liver failure was type C liver cirrhosis (50%), fulminant hepatitis (25%), type B liver cirrhosis (12%), and alcoholic liver cirrhosis (12%). The median Child-Pugh score and MELD score were 13 points (range, 8-15 points) and 19 points (range, 10-18 points), respectively. The living related donor was the recipient's child (75%), sibling (12%), or parent (12%). ABO compatibility was identical in 62%, compatible in 25%, and incompatible in 12%.
    Conclusions. In this study, we evaluated the adult patients who successfully withdrew from IS agents after LDLT. In most cases, it took more than 5 years to reduce IS agents. Because monitoring of the serum transaminase level is not adequate to detect chronic liver fibrosis in immune tolerance cases, further study is required to find appropriate protocols for reducing IS agent use after LDLT.

    DOI: 10.1016/j.transproceed.2015.12.093

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  • Development of the Intestinal Transplantation Model With Major Histocompatibility Complex Inbred CLAWN Miniature Swine 査読

    K. Miura, H. Sahara, S. Waki, A. Kawai, M. Sekijima, T. Kobayashi, Z. Zhang, T. Wakai, A. Shimizu, K. Yamada

    TRANSPLANTATION PROCEEDINGS48 ( 4 ) 1315 - 1319   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Background. Clinical intestinal transplantation (Int-Tx) is associated with some problems such as rejection, infection, graft-versus-host disease, and ischemia-reperfusion injury (IRI). To determine mechanisms of rejection as well as to develop treatment strategies for Int-Tx, this study was designed to establish both heterotopic and orthotropic Int-Tx models using major histocompatibility antigen complex (MHC) inbred CLAWN miniature swine.
    Materials and Methods. Eleven CLAWN miniature swine received MHC matched but minor antigen mismatched allogenic intestinal grafts. Four animals received intestinal grafts heterotopically and kept host intestine intact. The remaining 7 animals received intestinal grafts orthotopically and resected host small intestine. Continuous infusion of tacrolimus was given from day 0 for 12 days.
    Results. Heterotopically transplanted small intestine were well perfused after revascularization; however, grafts easily underwent ischemic changes during or soon after abdomen closure due to oppression of the grafts in the limited abdominal space. In contrast, all of 7 orthotopically transplanted intestinal grafts in which recipients' small intestine was removed from the jejunum to the ileum had no signs of severe ischemia associated with compartment syndrome. Elevation of the serum concentration of inflammatory cytokines and the progression of lethal acidosis seen in recipients of heterotipic transplantation were markedly less in the case of orthotopic transplantation. Two recipients survived more than 30 days, and 1 long-term survivor showed no evidence of rejection at day 90 despite the fact that tacrolimus was stopped at day 12.
    Conclusions. In this study, we demonstrated the establishment of a clinically relevant orthotopic Int-Tx model with long survival in MHC inbred CLAWN miniature swine. We believe that this unique MHC inbred swine Int-Tx model is useful for developing treatment strategies for clinical Int-Tx.

    DOI: 10.1016/j.transproceed.2016.01.023

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  • Successful Endoscopic Management of Acute Necrotic Pancreatitis and Walled Off Necrosis After Auxiliary Partial Orthotopic Living-Donor Liver Transplantation: A Case Report 査読

    T. Kobayashi, K. Miura, H. Ishikawa, D. Soma, Z. Zhang, K. Yuza, Y. Hirose, K. Takizawa, M. Nagahashi, J. Sakata, H. Kameyama, S. Kosugi, T. Wakai

    TRANSPLANTATION PROCEEDINGS48 ( 4 ) 1212 - 1214   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Endoscopic management of acute necrotic pancreatitis and walled off necrosis is less invasive than surgical treatment and has become the 1st choice for treating pancreatic necrosis and abscess. We treated a case of acute necrotic pancreatitis and walled off necrosis after auxiliary partial orthotopic living-donor liver transplantation (APOLT). A 24-year-old woman was admitted to our university hospital for removal of the internal biliary stent, which had already been placed endoscopically for the treatment of biliary stricture after APOLT. She had been treated for acute liver failure by APOLT 10 years before. After we removed the internal stent with the use of an endoscopic retrograde approach, she presented with severe abdominal pain and a high fever. Her diagnosis was severe acute pancreatitis after endoscopic retrograde cholangiography (ERC). Her symptoms worsened, and she had multiple organ failure. She was transferred to the intensive care unit (ICU). Immunosuppression was discontinued because infection treatment was necessary and the native liver had already recovered sufficiently. After she had been treated for 19 days in the ICU, she recovered from her multiple organ failure. However, abdominal computerized tomography demonstrated the formation of pancreatic walled off necrosis and an abscess on the 20th day after ERC. We performed endoscopic ultrasonography-guided abscess drainage and repeated endoscopic necrosectomy. The walled off necrosis diminished gradually in size, and the symptoms disappeared. The patient was discharged on the 87th day after ERC. This is the 1st report of a case of acute necrotic pancreatitis and walled off necrosis that was successfully treated by endoscopic management after APOLT.

    DOI: 10.1016/j.transproceed.2015.12.113

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  • Successful Re-resection for Locally Recurrent Retroperitoneal Liposarcoma at Four Years After Ex Vivo Tumor Resection and Autotransplantation of the Liver: A Case Report. 査読

    Kobayashi T, Miura K, Ishikawa H, Soma D, Zhang Z, Yuza K, Hirose Y, Takizawa K, Nagahashi M, Sakata J, Kameyama H, Kosugi S, Wakai T

    Transplantation proceedings48 ( 4 ) 1215 - 1217   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.transproceed.2016.01.026

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  • Six-Year Graft Survival After Partial Pancreas Heterotopic Auto-Transplantation: A Case Report 査読

    T. Kobayashi, K. Miura, H. Ishikawa, D. Soma, Z. Zhang, K. Yuza, Y. Hirose, K. Takizawa, M. Nagahashi, J. Sakata, H. Kameyama, S. -I. Kosugi, T. Tada, H. Hirukawa, T. Wakai

    TRANSPLANTATION PROCEEDINGS48 ( 3 ) 988 - 990   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Background. Long-term graft survival of partial pancreas auto-transplantation after total pancreatectomy has not been clarified. The clinical implications of repeat completion pancreatectomy for locally recurrent pancreatic carcinoma in the remnant pancreas after initial pancreatectomy also have not been clarified.
    Methods. We have previously reported a 61-year-old woman presenting with re-sectable carcinoma of the remnant pancreas at 3 years after undergoing a pylorus-preserving pancreaticoduodenectomy for invasive ductal carcinoma of the pancreas head. We also performed distal pancreas auto-transplantation with the use of a part of the resected pancreas to preserve endocrine function.
    Results. The patient was discharged at 20 days after surgery without any complications. She had been followed regularly in our outpatient clinic. She had been treated with S-1 as adjuvant chemotherapy; 72 months after the completion total pancreatectomy with distal partial pancreas auto-transplantation, the patient was alive without any evidence of the pancreatic carcinoma recurrence. The pancreas graft was still functioning with a blood glucose level of 112 mg/dL, HbA1C of 6.7%, and serum C-peptide of 1.2 ng/mL; and urinary C-peptide was 11.6 mu g/d.
    Conclusions. Our patient demonstrated that repeated pancreatectomies can provide a chance for survival after a locally recurrent pancreatic carcinoma if the disease is limited to the remnant pancreas. An additional partial pancreas auto-transplantation was successfully performed to preserve endocrine function. However, the indications for pancreas auto transplantation should be decided carefully in the context of pancreatic carcinoma recurrence.

    DOI: 10.1016/j.transproceed.2016.01.030

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  • [A Case of Solitary Paraaortic Lymph Node Recurrence after Surgical Resection for Combined Hepatocellular and Cholangiocarcinoma]. 査読

    Hirose Y, Sakata J, Yuza K, Soma D, Sudo N, Ishikawa H, Tatsuda K, Miura K, Takizawa K, Takano K, Nagahashi M, Kobayashi T, Kameyama H, Kosugi S, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy42 ( 12 ) 1860 - 1862   2015年11月

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  • [Repeated Pancreatic Resections with Parenchymal Preservation for Pancreatic Metastases of Renal Cell Carcinoma--Report of a Case]. 査読

    Ishikawa H, Sakata J, Soma D, Yuza K, Ando T, Hirose Y, Miura K, Tatsuda K, Ohashi T, Takizawa K, Nagahashi M, Kameyama H, Kobayashi T, Kosugi S, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy42 ( 12 ) 2254 - 2255   2015年11月

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  • [A Case of Rectal Carcinoma with Recurrence around the Drainage Site Complicated by Fournier's Gangrene]. 査読

    Abe K, Kameyama H, Shimada Y, Yamada S, Soma D, Yagi R, Miura K, Tatsuda K, Tajima Y, Okamura T, Nakano M, Nakano M, Kobayashi T, Kosugi S, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy42 ( 12 ) 2291 - 2293   2015年11月

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  • [A Case of Radical Resection for Locally Advanced Pancreatic Cancer with Positive Peritoneal Cytology Treated with Chemoradiotherapy]. 査読

    Sato R, Takizawa K, Yuza K, Soma D, Hirose Y, Morimoto Y, Miura K, Nagahashi M, Takano K, Sakata J, Kameyama H, Kobayashi T, Minagawa M, Kosugi S, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy42 ( 12 ) 2385 - 2387   2015年11月

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  • [Signet-Ring Cell Carcinoma of the Ampulla of Vater--Report of a Case]. 査読

    Yuza K, Sakata J, Soma D, Ando T, Hirose Y, Ishikawa H, Miura K, Tatsuda K, Ohashi T, Takizawa K, Nagahashi M, Kameyama H, Kobayashi T, Kosugi S, Wakai T

    Gan to kagaku ryoho. Cancer & chemotherapy42 ( 12 ) 1767 - 1769   2015年11月

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  • Protective Effect of Neutralization of the Extracellular High-Mobility Group Box 1 on Renal Ischemia-Reperfusion Injury in Miniature Swine 査読

    Kohei Miura, Hisashi Sahara, Mitsuhiro Sekijima, Akihiro Kawai, Shiori Waki, Hiroaki Nishimura, Kentaro Setoyama, Eric S. Clayman, Akira Shimizu, Kazuhiko Yamada

    TRANSPLANTATION98 ( 9 ) 937 - 943   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background Strategies that reduce ischemia-reperfusion injury (IRI) have the potential to expand the numbers of available organs for transplantation. Recent reports in rodent models have demonstrated that high-mobility group box 1 (HMGB1) acts as an alarm in initiating the inflammatory response resulting from ischemic injury. The aim of this study was to evaluate the cytoprotective effects of anti-HMGB1 antibodies on renal IRI in preclinical large animals.
    Methods One hundred twenty minutes of warm and 60 min of cold renal ischemia were induced in 8 CLAWN miniature swine. Three of eight animals received intravenous anti-HMGB1 antibody at 1 mg/kg just before the reperfusion of renal blood flow. Renal function was assessed by serum creatinine and renal biopsy. Serum levels of interleukin (IL)-1, IL-6, and HMGB1 were measured.
    Results The concentration of HMGB1 increased as early as 30 min after reperfusion and before the elevation of IL-1 and IL-6. Serum creatinine levels were markedly elevated, peaking at a median of 5 days (peak creatinine levels: 11.61.6 mg/dL) and recovering by day 14. Anti-HMGB1 antibody injection dramatically decreased renal damage as well as serum levels of HMGB1 associated with IRI. Renal function returned to near normal by day 9, and peak creatinine levels were markedly lower (7.4 +/- 0.2 mg/dL), and biopsies possessed fewer pathologic changes when compared to the control group.
    Conclusion In this study, we demonstrated the beneficial effects of perioperative administration of anti-HMGB1 antibody in reducing renal IRI in a clinically relevant, large animal model.

    DOI: 10.1097/TP.0000000000000358

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  • Laparoscope-assisted Hassab's Operation for Esophagogastric Varices After Living Donor Liver Transplantation: A Case Report 査読

    T. Kobayashi, K. Miura, H. Ishikawa, H. Oya, Y. Sato, M. Minagawa, J. Sakata, K. Takano, K. Takizawa, H. Nogami, S. -I. Kosugi, T. Wakai

    TRANSPLANTATION PROCEEDINGS46 ( 3 ) 986 - 988   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    This is the first successful report of a laparoscope-assisted Hassab's operation for esophagogastric varices after living donor liver transplantation (LDLT). A 35-year-old man underwent LDLT using a right lobe graft as an aid for primary sclerosing cholangitis (PSC) in 2005. Follow-up endoscopic and computed tomography (CT) examinations showed esophagogastric varices with splenomegaly in 2009 that increased (esophageal varices [EV]: locus superior [Ls], moderator enlarged, beady varices [F2], medium in number and intermediate between localized and circumferential red color signs [RC2]; gastric varices [GV]: extension from the cardiac orifice to the fornix [Lg-cf], moderator enlarged, beady varices [F2], absent red color signs [RC0]). A portal venous flow to the esophagogastric varices through a large left gastric vein was also confirmed. Preoperative Child-Pugh was grade B and score was 9. Because these esophagogastric varices had a high risk of variceal bleeding, we proceeded with a laparoscope-assisted Hassab's operation. Operative time was 464 minutes. Blood loss was 1660 mL. A graft liver biopsy was also performed and recurrence of PSC was confirmed histologically. It was suggested that portal hypertension and esophagogastric varices were caused by recurrence of PSC. Postoperative complications were massive ascites and enteritis. Both of them were treated successfully. This patient was discharged on postoperative day 43. Follow-up endoscopic study showed improvement in the esophagogastric varices (esophageal varices [EV]: locus superior [Ls], no varicose appearance [F0], absent red color signs [RC0], gastric varices [GV]: adjacent to the cardiac orifice [Lg-c], no varicose appearance [F0], absent red color signs [RC0]) at 6 months after the operation. We also confirmed the improvement of esophagogastric varices by serial examinations of CT.

    DOI: 10.1016/j.transproceed.2013.10.047

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  • Catheter-directed continuous thrombolysis following aspiration thrombectomy via the ileocolic route for acute portal venous thrombosis: report of two cases 査読

    Kohei Miura, Yoshinobu Sato, Hideki Nakatsuka, Satoshi Yamamoto, Hiroshi Oya, Yoshiaki Hara, Hidenaka Kokai, Katsuyoshi Hatakeyama

    SURGERY TODAY43 ( 11 ) 1310 - 1315   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Although acute portal venous thrombosis (PVT) is a potentially life-threatening complication that occurs after hepatobiliary surgery with portal vein (PV) reconstruction or splenectomy, no effective or universal treatments have yet been established. Transjugular or transhepatic catheter-directed thrombolysis has recently been reported to be effective for treating acute PVT. However, the efficiency of this treatment for complete PV occlusion might be limited because a poor portal venous flow prevents thrombolytic agents from reaching and dissolving thrombi. Moreover, the use of the transjugular or transhepatic route might not be suitable in patients who have undergone major hepatectomy or in those with ascites due to an increased risk of residual liver injury or intra-abdominal bleeding following puncture to the residual liver. We herein describe the cases of two patients with almost total PV occlusion caused by massive thrombi that formed after hepatobiliary surgery, who were successfully treated with catheter-directed continuous thrombolysis following aspiration thrombectomy via the ileocolic route. This treatment should be considered beneficial for treating selected patients such as the two patients described herein.

    DOI: 10.1007/s00595-012-0343-1

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  • Perioperative Immunological Differentiation in Liver Cirrhotic Patients who Underwent Living Related Liver Transplantation 査読

    Yoshinobu Sato, Chikako Tomiyama, Satoshi Yamamoto, Hiroshi Oya, Takashi Kobayashi, Hidenaka Kokai, Kohei Miura, Yuki Hirose, Katsuyoshi Hatakeyama

    HEPATO-GASTROENTEROLOGY60 ( 124 ) 666 - 668   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:H G E UPDATE MEDICAL PUBLISHING S A  

    Background/Aims: Liver cirrhotic patients are immunological compromised hosts. Preoperative status in cirrhotic patients affects postoperative infection complications. This study investigates the perioperative immunological changes in the differentiation by MELD score. Methodology: Fifteen patients underwent LDLT and were divided two groups, Group I (n=5, MELD score >= 20) and Group II (n=10, MELD score <20). Immunological status of cirrhotic patients was analyzed for Th1, Th2, Treg and Th17 by flow cytometry using monoclonal antibody CD3/CD19,CD4/8, FoxP3, IL-17, IFN-gamma and TNF-alpha. Results: T cell decreased and increased gradually following LDLT. The preoperative T cell count of MELD score 33 patients was very low. CD4 and CD8 T cells also decreased after LDLT. The preoperative CD8(+) T cell count of MELD score 33 patients was very low. Th17 decreased and recovered gradually in the all patients after LDLT. However Th17 of MELD score 33 did not recover. IFN-gamma-producing cells in naive T cells decreased after LDLT. Preoperatively those in the Group I was lower than those in the Group II. The population of Treg decreased in the Group I, however, it increased in the Group II on 7 days after LDLT. Conclusions: The patients with MELD score >20 showed a decrease of cytotoxic immunity with both diminution and delay of CD8+ T cells and Th17 helper T cells. The cytotoxic immunity of the patients with MELD score <20 was maintained and recovered in the early period after LDLT. The patients with MELD score >20 might be at high risk of infection after LDLT.

    DOI: 10.5754/hge

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  • Heterotopic pancreas autotransplantation with spleen for uncontrollable hemorrhagic pseudocyst and disabling pain in chronic pancreatitis 査読

    Yoshinobu Sato, Hiroshi Oya, Satoshi Yamamoto, Hidenaka Kokai, Kohei Miura, Katsuyoshi Hatakeyama

    Hepato-Gastroenterology60 ( 123 ) 425 - 427   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background/Aims: In this study, we report on a heterotopic segmental pancreatic autotransplantation (HPAT) with spleen for alcoholic chronic pancreatitis with uncontrollable hemorrhagic pseudocyst and complete portal venous obstruction. The patient was a 72-year-old man who had an alcoholic chronic pancreatitis with severe abdominal pain and hemorrhagic pseudocyst. The first bleeding from a pseudoaneurism of the gastro-duodenal artery (GDA) to the cyst of pancreas head was stopped by interventional radiology (IVR) at our hospital on May 2010. The second bleeding happened with severe abdominal pain on February 15th, 2011
    he was admitted on February 17. The IVR was not successful. Methodology: There were two problems for the operation. The first was the severe inflammation and the second was the control of hemorrhage from GDA. We were afraid of the postoperative hemorrhage due to the leakage of pancreatic juice in the pancreato-duodenectomy (PD). Therefore, we chose the HPAT as a solution for postoperative hemorrhage and severe abdominal pain. After complete duodeno-pancreatectomy with spleen, we performed HPAT with spleen on March 8, 2011. The pancreatic duct reconstruction was performed by Roux-en-Y anastomosis to the jejunum. Results: The postoperative course was uneventful. The abdominal pain had resolved completely and the patient remained normoglycemic after HPAT. Conclusions: We conclude that HPAT is a useful option for hemorrhagic pseudocyst of the pancreas head with severe abdominal pain of chronic pancreatitis. © H.G E. Update Medical Publishing S.A.

    DOI: 10.5754/hge12805

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  • Successful laparoscopic division of a patent ductus venosus: report of a case 査読

    Yoshiaki Hara, Yoshinobu Sato, Satoshi Yamamoto, Hiroshi Oya, Masato Igarashi, Satoshi Abe, Hidenaka Kokai, Kohei Miura, Takeshi Suda, Minoru Nomoto, Yutaka Aoyagi, Katsuyoshi Hatakeyama

    SURGERY TODAY43 ( 4 ) 434 - 438   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Patent ductus venosus (PDV) is a rare condition of a congenital portosystemic shunt from the umbilical vein to the inferior vena cava. This report presents the case of an adult patient with PDV, who was successfully treated with laparoscopic shunt division. A 69-year-old male was referred with hepatic encephalopathy. Contrast-enhanced CT revealed a large connection between the left portal vein and the inferior vena cava, which was diagnosed as PDV. The safety of a shunt disconnection was confirmed using a temporary balloon occlusion test for the shunt, and the shunt division was performed laparoscopically. The shunt was carefully separated from the liver parenchyma with relative ease, and then divided using a vascular stapler. Portal flow was markedly increased after the operation, and the liver function of the patient improved over the 3-month period after surgery. Although careful interventional evaluation for portal flow is absolutely imperative prior to surgery, a minimally invasive laparoscopic approach can be safely used for treating PDV.

    DOI: 10.1007/s00595-012-0316-4

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  • Successful Laparoscopic-Assisted Hemostasis of Intrathoracic Massive Vericeal Rupture During Living Related Liver Transplantation: A Case Report 査読

    Y. Sato, H. Oya, S. Yamamoto, H. Kokai, K. Miura, K. Hatakeyama

    TRANSPLANTATION PROCEEDINGS44 ( 3 ) 820 - 821   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    End-stage liver disease that requires transplantation is usually accompained by esophagogastric or another collateral vessel varices. Sometimes, the esophagogastric varices rupture intraoperatively during liver transplantation. However we have reported rare case of rupture of an intercostal varicose vein, which was controlled successfully by flexible laparoscopy. The patient was a 62-year-old man, who suffered decompensated liver cirrhosis with hepatocellular carcinoma. The Child-Pugh score was 11 and the Model for End-stage Liver Diseases score was 14. Preoperative gastrointestinal fiberscopy and colon fiberscopy examinations revealed esophagogastric and rectal varices. He underwent living related liver transplantation from his son on February 10, 2010. Just after the liver transplantation, the patient's blood pressure tended to decrease. Chest radiography demonstrated a massive right pleural effusion. We drained 3000 mL of blood by thoracic puncture. Therefore we reoperated him for the question an intrathoracic variceal hemorrhage. We confirmed variceal bleeding after removal of the massive hematoma by opening the diaphragm. However, we could neigher show directly the bleeding point in the anterior thorax nor stop it because of the constriction of the diaphragm. Therefore we used a flexible laparoscope to both confirm the bleeding point and to achieve hemostasis. We believe that theoperative compression of the intercostal varicose vein by a retractor induced the vascular rupture.

    DOI: 10.1016/j.transproceed.2012.03.031

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  • Magnetic Compression Anastomosis for Bile Duct Stenosis After Donor Left Hepatectomy: A Case Report 査読

    H. Oya, Y. Sato, E. Yamanouchi, S. Yamamoto, Y. Hara, H. Kokai, T. Sakamoto, K. Miura, K. Shioji, Y. Aoyagi, K. Hatakeyama

    TRANSPLANTATION PROCEEDINGS44 ( 3 ) 806 - 809   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Magnetic compression anastomosis (MCA) provides a minimally invasive treatment creating a nonsurgical, sutureless enteric anastomosis in conjunction with an interventional radiologic technique by using 2 high-power magnets. Recently, the MCA technique has been applied to bile duct strictures after living donor liver transplantation or major hepatectomy. Herein we described use of MCA for bile duct stenosis 5 months after donor left hepatectomy in a 24-year-old man who presented with a stricture at the porta hepatis and intrahepatic bile duct dilatation. Unsuccessful transpapillary biliary drainage and balloon dilatation through a percutaneous transhepatic biliary drainage (PTBD) route led to the MCA. A 4-mm-diameter cylindrical samarium-cobalt (Sm-Co) daughter magnet with a long nylon wire was placed at the superior site of the obstruction through the PTBD route. A 5-mm-diameter Sm-Co parent magnet with an attached nylon handle was endoscopically inserted into the common bile duct and placed at the inferior site of obstruction. The 2 magnets were attracted, sandwiching the stricture and establishing a reanastomosis. In conclusion, the MCA technique was a unique procedure for choledochocholedochostomy in a patient with bile duct stenosis after donor hepatectomy.

    DOI: 10.1016/j.transproceed.2012.01.021

    Web of Science

    PubMed

  • Liver Transplantation Surgical Techniques for Extensive Retroperitoneal Tumor With Major Blood Vessel Involvement: A Case Report 査読

    K. Miura, Y. Sato, H. Kokai, Y. Hara, T. Kobayashi, H. Oya, S. Yamamoto, K. Hatakeyama

    TRANSPLANTATION PROCEEDINGS44 ( 2 ) 579 - 580   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    A case of a 71-year-old man with a huge retroperitoneal tumor situated behind the liver, which strongly compressed the liver inferior vena cava (IVC), and gastrointestinal tract is described. With the techniques of whole liver extraction and autologous orthotopic liver transplantation, we successfully removed the tumor. We have the surgical techniques, essential elements, and indications for this procedure.

    DOI: 10.1016/j.transproceed.2012.01.074

    Web of Science

    PubMed

  • Regulatory T-Cell Activation among Patients Who Displayed Operational Tolerance following Intra-portal Administration of Donor-Specific Antigens in Living Donor Liver Transplantation 査読

    Y. Sato, T. Chikako, H. Oya, S. Yamamoto, H. Kokai, K. Miura, K. Hatakeyama

    TRANSPLANTATION PROCEEDINGS44 ( 2 ) 560 - 564   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Immunologic tolerance is the goal for all transplant surgeons. We have reported that repeated donor-specific antigen transfusion (DST) via the portal vein allowed rapid reduction of immunosuppressants with decreased acute cellular rejection episodes among living donor liver transplantations (LDLT). Moreover, we demonstrated that intraportal DST induced macrochimerism of donor type CD56 T cells in the liver graft. We examined the impact of FoxP3(+)CD4 CD25(+) T cells in recipients who acquired almost tolerance after LDLT with intraportal DST. We defined the amount of immunosuppressants administered less than one time per week as "almost tolerance" after LDLT, which occurred among 14% of DST patients after adult-to-adult LDLT. Two patients (4%) have gotten been we used from immunosuppressants more than 2 years after LDLT 4 years prior. We examined the impact of FoxP3(+)CD4(+)CD25(+) T cells both in recipients with almost daily immunosuppressants and those who acquired almost tolerance. The proportion of FoxP3+/CD4+CD25 T cells in the almost tolerance group was significantly higher than that in the almost daily immunosuppressant group (P <.05). The increased proportion of FoxP3(+)/CD4 CD25(+) T cells significantly correlated with time after LRLT (y = 0.0964x + 42.02, R-2 = 0.8854). Repeated intraportal DST may be a goot tool to induce immunologic tolerance after LDLT. Both donor type CD56(+) T cells and FoxP3(+)/CD4(+)CD25(+) T cells may act as important regulatory cells for tolerance. The period after LDLT is important for acquiring immunologic tolerance.

    DOI: 10.1016/j.transproceed.2012.01.045

    Web of Science

    PubMed

  • Isolated Dissection of the Superior Mesenteric Artery After Living Donor Liver Transplantation: A Case Report 査読

    H. Kokai, Y. Sato, S. Yamamoto, H. Oya, T. Kobayashi, T. Watanabe, K. Miura, K. Hatakeyama

    TRANSPLANTATION PROCEEDINGS44 ( 2 ) 588 - 590   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Isolated dissection of the superior mesenteric artery (SMA) not associated with aortic dissection is rare, particularly after living donor liver transplantation (LDLT). We experienced a case of isolated dissection of the SMA after LDLT performed in a 56-year-old man diagnosed with hepatitis B virus related cirrhosis and hepatocellular carcinoma within the Milan criteria. He had no past history of hypertension or diabetes mellitus. At 6 days after LDLT, the patient underwent an emergency portal vein thrombectomy with ligation of a huge left gastric vein shunt. Thereafter anticoagulant and antiplatelet therapy were initiated. At 12 days after LDLT, a contrast-enhanced computer assisted tomography (CT) scan revealed the presence of a thrombus in a false lumen and a thin flap enlarged in the SMA. Because he presented neither abdominal pain nor biochemical data suggesting mesenteric ischemia, he was treated with antihypertensive agents in addition to anticoagulant and antiplatelet therapy. The thrombus in the false lumen was reduced and the intimal flap in the SMA disappeared according to the results of a CT scan 4 months after LDLT. He has remained free of symptoms for 4 years. The strategy to treat isolated SMA dissection is not well established. Urgent surgery is indicated for acute symptomatic forms with a suspicion of mesenteric ischemia; conservative treatment is indicated for patients with minimal, resolving, or no pain, but requires close follow-up.

    DOI: 10.1016/j.transproceed.2012.01.020

    Web of Science

    PubMed

  • A New Technique of Lateral Approach for Laparoscopy-Assisted Donor Left Hepatectomy 査読

    Hiroshi Oya, Yoshinobu Sato, Satoshi Yamamoto, Yoshiaki Hara, Takashi Kobayashi, Takaoki Watanabe, Hidenaka Kohai, Kohei Miura, Katsuyoshi Hatakeyama

    HEPATO-GASTROENTEROLOGY58 ( 110 ) 1765 - 1768   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:H G E UPDATE MEDICAL PUBLISHING S A  

    This report describes laparoscopy-assisted donor left hepatectomy preserving the caudate lobe (LADLH), and a new technique for hand-assisted liver transection between the left lobe and the caudate lobe beforehand, called the "lateral approach." Four donor patients underwent LADLH. Preoperative computed tomography investigated the depth and width between the left lobe and the caudate lobe from the Arantius duct. LADLH was performed through a 9cm midline epigastric hand-port incision with four ports. The confluence of the middle and left hepatic veins was encircled with tape. Hand-assisted liver transection between the left lobe and the caudate lobe was performed using laparosonic coagulating shears after precoagulation with radio frequency ablation under ultrasonograph.ic guidance. Through the hand-port incision, the tape around the middle and left hepatic veins could be passed between the left lobe and the caudate lobe to the porta hepatis. We used the tape toward the end of the parenchymal transection to bring the transection plane closer to the surface. The liver parenchyma was divided at Cant lie's line under direct vision. The graft was extracted through the hand-port incision. All donors underwent LADLH completely without any intraoperative complication. None of the donors required transfusion or re-operation.

    DOI: 10.5754/hge11152

    Web of Science

    PubMed

▶ 全件表示

MISC

  • MHC確立クラウン系ミニブタを用いた肝・小腸移植モデルにおける免疫寛容誘導の確立

    関島 光裕, 佐原 寿史, 小川 勇一, 三木 克幸, 室川 剛廣, 三浦 宏平, 岩永 健裕, 市成 ゆりか, 渕之上 昌平, 清水 章, 山田 和彦

    移植53 ( 総会臨時 ) 504 - 504   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 同種膵島移植実験を見据えたブタ1型糖尿病モデルおよび自家膵島移植モデルの確立

    三浦 宏平, 小林 隆, 石川 博補, 相馬 大輝, 安藤 拓也, 油座 築, 廣瀬 雄己, 堅田 朋大, 滝沢 一泰, 坂田 純, 田島 陽介, 角田 知行, 市川 寛, 羽入 隆晃, 永橋 昌幸, 中島 真人, 島田 能史, 亀山 仁史, 若井 俊文

    日本外科学会定期学術集会抄録集118回   2444 - 2444   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 乳児生体肝移植後早期の門脈血栓症に対する門脈ステント留置

    大矢 雄希, 内田 皓士, 川端 誠一, 橋本 晋太朗, 三浦 宏平, 磯野 香織, 林田 信太郎, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    日本小児外科学会雑誌54 ( 1 ) 59 - 63   2018年1月

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    記述言語:日本語   出版者・発行元:(NPO)日本小児外科学会  

    症例は7ヵ月の女児。生後68日に胆道閉鎖症に対して葛西手術を施行するも減黄不十分で肝不全が進行し、母親をドナーとする生体肝移植を施行した。減寸外側区域グラフトを用い、門脈はパッチグラフトで形成した。術後8日目に、浮腫の増悪と急速な腹水増加があり、腹部超音波にて肝内門脈腔は認めるものの血流確認できず本幹に血栓を認めた。そのため、同日に緊急で経皮経肝門脈造影を行い、カテーテルが血栓部位を通過したのち、上腸間膜静脈から造影すると、肝内門脈は、ほとんど造影されなかった。そのため、7mm〜4cmのメタルステントの留置を行い、肝内門脈への血流が再開した。その後、低分子ヘパリンによる抗凝固を開始し、ワーファリンに移行した。術後45日で退院となり、術後半年時点での門脈血流は良好である。乳児であり、また術後比較的早期のステント留置で適応に関する議論の余地はあるが、低侵襲で効果的な治療であった。(著者抄録)

    DOI: 10.11164/jjsps.54.1_59

  • 小児下部消化管、感染 膵性腹水を合併した幼児膵嚢胞の1症例

    川端 誠一, 林田 信太郎, 磯野 香織, 内田 皓士, 大矢 雄希, 三浦 宏平, 山本 栄和, 興梠 雅弘, 菅原 寧彦, 猪股 裕紀洋

    日本小児外科学会雑誌53 ( 6 ) 1223 - 1223   2017年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本小児外科学会  

  • 小児移植・悪性腫瘍 傍腫瘍性神経症候群を呈した18歳女子神経芽腫再発の1例

    内田 皓士, 川端 誠一, 吉井 大貴, 三浦 宏平, 磯野 香織, 大矢 雄希, 林田 信太郎, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    日本小児外科学会雑誌53 ( 6 ) 1221 - 1221   2017年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本小児外科学会  

  • 肝移植手術の手技の伝承と応用 手術手技向上における多施設共同での肝移植医療人養成プログラムの効果と課題 六大学連携プログラム

    山本 栄和, 高木 弘誠, 中沼 伸一, 三浦 宏平, 嶋田 圭太, 菅原 寧彦, 猪股 裕紀洋

    日本消化器外科学会総会72回   SY12 - 8   2017年7月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

  • 肝移植手術の手技の伝承と応用 肝移植における血行再建手術手技の消化器外科手術への応用

    林田 信太郎, 三浦 宏平, 大矢 雄希, 山本 栄和, 菅原 寧彦, 近本 亮, 馬場 秀夫

    日本消化器外科学会総会72回   O2 - 77   2017年7月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

  • 安全・安心な臓器移植のために出来ること 当院における肝移植後の肝静脈狭窄の検討

    大矢 雄希, 菅原 寧彦, 内田 皓士, 川端 誠一, 三浦 宏平, 吉井 大貴, 磯野 香織, 林田 信太郎, 山本 栄和, 猪股 裕紀洋

    日本消化器外科学会総会72回   SY04 - 8   2017年7月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

  • 生体肝移植における尾状葉付き左葉グラフトの使用経験

    嶋田 圭太, 成田 泰子, 宇戸 啓一, 三浦 宏平, 林田 信太郎, 大矢 雄希, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    日本消化器外科学会総会72回   PN13 - 5   2017年7月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

  • 当院におけるドミノ肝移植の成績およびドミノ肝移植2次レシピエントの長期予後の検討

    三浦 宏平, 成田 泰子, 林田 信太郎, 大矢 雄希, 山本 栄和, 小林 隆, 若井 俊文, 菅原 寧彦, 猪股 裕紀洋

    日本消化器外科学会総会72回   PN14 - 3   2017年7月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

  • 乳児生体肝移植後早期の門脈血栓症に対する門脈ステント留置

    大矢 雄希, 内田 皓士, 川端 誠一, 三浦 宏平, 吉井 大貴, 磯野 香織, 林田 信太郎, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    日本小児外科学会雑誌53 ( 4 ) 976 - 976   2017年6月

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    記述言語:日本語   出版者・発行元:(NPO)日本小児外科学会  

  • 人工肛門近傍グラフトに腸管狭窄を来し狭窄部腸管の部分切除を施行した脳死小腸移植術後長期生存症例

    川端 誠一, 阪本 靖介, 本田 正樹, 内田 皓士, 嶋田 圭太, 吉井 大貴, 三浦 宏平, 磯野 香織, 林田 信太郎, 大矢 雄希, 山本 栄和, 直江 秀昭, 菅原 寧彦, 猪股 裕紀洋

    移植52 ( 1 ) 73 - 80   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

    症例は18歳女性で、新生児期よりHirschsprung病類縁疾患の診断で人工肛門を造設し、中心静脈栄養(TPN)で管理していた。12歳時に脳死小腸移植術を施行した。術後、経口摂取も十分となり、中心静脈カテーテルは使用していなかった。明らかな拒絶反応なく経過し、約1年間経過が良好であった。このため、今回のエピソードの3ヵ月前(小腸移植術後5年4ヵ月時)に予防的に投与していたバルガンシクロビルとフルコナゾール投与を中止した。術後5年7ヵ月に上腹部痛が増強し、グラフト小腸内視鏡検査で人工肛門から約40cm口側までに多発する小腸潰瘍病変を認め、病理組織学的検査にてACRと診断し、ステロイドパルス療法を施行した。また免疫組織染色検査にてサイトメガロウイルス(CMV)腸炎と診断し、ガンシクロビルの投与、およびタクロリムスのトラフ値を調整した。小腸内視鏡検査では依然として人工肛門近傍グラフト腸管に狭窄した潰瘍病変が残存した。小腸潰瘍部を部分切除し、人工肛門を再造設した。術後経過は大きな問題なく経過し、経口摂取も十分可能で、腹部症状も改善したため術後13日目に退院した。

    DOI: 10.11386/jst.52.1_073

  • 生体肝移植後胆管狭窄に対する早期内視鏡的胆管造影の有用性

    相馬 大輝, 小林 隆, 三浦 宏平, 石川 博補, 安藤 拓也, 油座 築, 峠 弘治, 大橋 拓, 滝沢 一泰, 高野 可赴, 坂田 純, 永橋 昌幸, 亀山 仁史, 若井 俊文

    日本外科学会定期学術集会抄録集117回   PS - 205   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 生体肝移植ドナーの長期成績の検討

    小林 隆, 三浦 宏平, 石川 博補, 相馬 大輝, 安藤 拓也, 油座 築, 峠 弘治, 大橋 拓, 滝沢 一泰, 高野 可赴, 坂田 純, 永橋 昌幸, 亀山 仁史, 島田 能史, 市川 寛, 横田 直樹, 大山 俊之, 荒井 勇樹, 窪田 正幸

    日本外科学会定期学術集会抄録集117回   SF - 18   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 後区域グラフトを用いた成人生体肝移植症例の検討

    三浦 宏平, 内田 皓士, 川端 誠一, 吉井 大貴, 磯野 香織, 林田 信太郎, 大矢 雄希, 山本 栄和, 小林 隆, 若井 俊文, 菅原 寧彦, 猪股 裕紀洋

    日本外科学会定期学術集会抄録集117回   PS - 204   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 低出生体重で出生した胆道閉鎖症児に対する治療戦略

    林田 信太郎, 内田 皓士, 川端 誠一, 吉井 大貴, 三浦 宏平, 磯野 香織, 大矢 雄希, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    日本外科学会定期学術集会抄録集117回   PS - 205   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 当科における、胆道閉鎖症に対する小児生体肝移植患者の術後成長・発達について

    宇戸 啓一, 川端 誠一, 内田 皓士, 吉井 大貴, 磯野 香織, 三浦 宏平, 林田 信太郎, 大矢 雄希, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    日本小児外科学会雑誌53 ( 1 ) 197 - 197   2017年2月

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    記述言語:日本語   出版者・発行元:(NPO)日本小児外科学会  

  • 再移植を施行したPFIC1型の2例の検討

    大矢 雄希, 岡島 英明, 内田 皓士, 川端 誠一, 三浦 宏平, 吉井 大貴, 磯野 香織, 林田 信太郎, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    日本小児栄養消化器肝臓学会雑誌30 ( 2 ) 92 - 93   2016年12月

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    記述言語:日本語   出版者・発行元:日本小児栄養消化器肝臓学会  

  • 門脈血栓症例に対する肝移植の適応と成績 門脈血栓合併症例に対する成人生体肝移植術の検討

    三浦 宏平, 菅原 寧彦, 山本 栄和, 小林 隆, 若井 俊文, 猪股 裕紀洋

    日本臨床外科学会雑誌77 ( 増刊 ) 416 - 416   2016年10月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

  • HLAクラスIのみドナー優位のone way matchingで生体肝移植後GVHDを発症した1乳児例

    嶋田 圭太, 内田 皓士, 川端 誠一, 三浦 宏平, 吉井 大貴, 磯野 香織, 林田 信太郎, 大矢 雄希, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    移植51 ( 総会臨時 ) 373 - 373   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 成人生体肝移植における脾摘の功罪

    山本 栄和, 内田 皓士, 川端 誠一, 三浦 宏平, 吉井 大貴, 磯野 香織, 林田 信太郎, 大矢 雄希, 菅原 寧彦, 猪股 裕紀洋

    移植51 ( 総会臨時 ) 261 - 261   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 小児胆道閉鎖症に対する肝移植におけるreflow直後門脈血流不十分症例の危険因子解析

    橋本 晋太朗, 内田 皓士, 川端 誠一, 吉井 大貴, 磯野 香織, 三浦 宏平, 林田 信太郎, 大矢 雄希, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋

    移植51 ( 総会臨時 ) 259 - 259   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 生体ドナーによる小児再肝移植症例の検討

    三浦 宏平, 阪本 靖介, 嶋田 圭太, 磯野 香織, 本田 正樹, 林田 信太郎, 山本 栄和, 小林 隆, 若井 俊文, 猪股 裕紀洋

    日本消化器外科学会総会71回   P3 - 51   2016年7月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

  • 前臨床異種移植実験の進歩と今後の展開

    佐原 寿史, 関島 光裕, 三浦 宏平, 河合 彰浩, 田崎 正行, 岩永 健裕, 清水 章, 山田 和彦

    日本外科学会定期学術集会抄録集116回   OP - 089   2016年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 「国内初の、肝臓移植を担う高度医療人養成(SNUC-LT)」への参加 第一期履修生としての活動報告

    三浦 宏平, 小林 隆, 相馬 大輝, 油座 築, 廣瀬 雄己, 滝沢 一泰, 坂田 純, 皆川 昌広, 若井 俊文

    日本臨床外科学会雑誌77 ( 3 ) 713 - 713   2016年3月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

  • 国内初の、肝臓移植を担う高度医療人養成 (6大学連携プログラム)の取り組み

    高木 弘誠, 中沼 伸一, 三浦 宏平, 今村 一歩

    移植50 ( 4-5 ) 465 - 466   2015年10月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 生体肝移植後に発症した自己免疫性肝炎の一例

    相馬 大輝, 三浦 宏平, 小林 隆, 石川 博補, 油座 築, 廣瀬 雄己, 須藤 翔, 堅田 朋大, 大橋 拓, 佐藤 良平, 滝沢 一泰, 永橋 昌幸, 坂田 純, 亀山 仁史, 若井 俊文

    日本臨床外科学会雑誌76 ( 増刊 ) 886 - 886   2015年10月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

  • 臓器移植における新規技術・機器の導入 高圧下過冷却状態での革新的臓器保存法 前臨床クラウン系ミニブタモデルによる開発

    佐原 寿史, 関島 光裕, 三浦 宏平, 河合 彰浩, 脇 詩織, 岩永 健裕, 市成 ゆりか, 清水 章, 山田 和彦

    移植50 ( 総会臨時 ) 240 - 240   2015年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 肝胆膵 成人生体肝移植における免疫抑制剤完全離脱症例の検討

    三浦 宏平, 小林 隆, 相馬 大輝, 油座 築, 岡部 康之, 廣瀬 雄己, 森本 悠太, 佐藤 良平, 滝沢 一泰, 永橋 昌幸, 坂田 純, 亀山 仁史, 皆川 昌広, 小杉 伸一, 小山 諭, 若井 俊文

    日本外科学会定期学術集会抄録集115回   OP - 163   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 劇症肝炎に対する脳死肝移植の1例

    相馬 大輝, 三浦 宏平, 小林 隆, 石川 博補, 滝沢 一泰, 永橋 昌幸, 坂田 純, 皆川 昌広, 小杉 伸一, 若井 俊文

    新潟医学会雑誌129 ( 4 ) 216 - 220   2015年4月

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    記述言語:日本語   出版者・発行元:新潟医学会  

    今回、術前に敗血症を呈した亜急性型劇症肝炎に対し脳死肝移植を施行し救命し得た症例を経験したので文献的考察を加えて報告する。症例は62歳、男性。薬剤性亜急性型劇症肝炎として近医にて加療されるも改善なく、肝移植目的に当院に転院した。転院4日目に脳症の増悪を認め緊急生体肝移植の方針となったが、カテーテル感染による敗血症性ショック、重度の呼吸不全、腎不全のため手術を延期し、保存的に加療を継続した。その後ショックから離脱し、血液培養の陰性化を確認した。転院10日目に脳死ドナーが発生したため脳死全肝移植を施行した。手術直前に採取した血液培養検査が陽性であったため結果的には菌血症状態での肝移植となった。術後早期より持続的血液濾過透析、エンドトキシン吸着療法を開始し、タクロリムス血中濃度を低値に抑えることで全身状態は比較的速やかに改善した。その後重篤な合併症なく第10病日にICU退室した。術前に敗血症を呈した症例に対する肝移植の成績は極めて不良であるが、術後の集中管理により救命し得たので報告する。(著者抄録)

  • 肝胆膵 当院における劇症肝炎症例に対する生体肝移植の経験

    相馬 大輝, 小林 隆, 三浦 宏平, 油座 築, 岡部 康之, 廣瀬 雄己, 森本 悠太, 佐藤 良平, 滝沢 一泰, 永橋 昌幸, 坂田 純, 亀山 仁史, 皆川 昌広, 小杉 伸一, 小山 論, 若井 俊文

    日本外科学会定期学術集会抄録集115回   RS - 16   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • MHC確立ならびに遺伝子ノックアウト大動物を用いた同種・異種移植前臨床実験 鹿児島大学異種移植外科での経験

    三浦 宏平

    今日の移植28 ( 1 ) 87 - 90   2015年2月

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    記述言語:日本語   出版者・発行元:(株)日本医学館  

  • 劇症肝炎に対する脳死移植の1経験

    相馬 大輝, 小林 隆, 三浦 宏平, 石川 博補, 滝沢 一泰, 坂田 純, 皆川 昌広, 若井 俊文

    日本臨床外科学会雑誌75 ( 12 ) 3399 - 3399   2014年12月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

  • 膵癌術後難治性リンパ瘻を外科的に治療しえた腎移植後患者の1例

    安藤 拓也, 皆川 昌広, 滝沢 一泰, 高野 可赴, 油座 築, 廣瀬 雄己, 三浦 宏平, 永橋 昌幸, 島田 能史, 坂田 純, 亀山 仁史, 小林 隆, 小杉 伸一, 小山 諭, 若井 俊文

    日本臨床外科学会雑誌75 ( 増刊 ) 660 - 660   2014年10月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

  • 生体肝移植後胆管結石症例の検討

    小林 隆, 坂田 純, 皆川 昌広, 三浦 宏平, 島田 能史, 亀山 仁史, 小杉 伸一, 石川 卓, 羽入 隆晃, 若井 俊文

    日本消化器外科学会総会69回   RS - 42   2014年7月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

  • MHC確立ミニブタ前臨床腎移植モデルを用いた温虚血障害腎に対する常温臓器保存の有効性の検討

    河合 昭浩, 佐原 寿史, 関島 光裕, 三浦 宏平, 脇 詩織, 清水 章, 山田 和彦

    泌尿器科紀要60 ( 7 ) 343 - 343   2014年7月

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    記述言語:日本語   出版者・発行元:泌尿器科紀要刊行会  

  • MHC確立ミニブタ肺移植モデルを用いた新規ドナー臓器保護剤としての硫化水素の可能性評価

    佐原 寿史, 三浦 宏平, 河合 昭浩, 脇 詩織, 清水 章, 山田 和彦

    日本呼吸器外科学会雑誌28 ( 3 ) O20 - 3   2014年4月

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    記述言語:日本語   出版者・発行元:(NPO)日本呼吸器外科学会  

  • MHC確立クラウンミニブタ小腸移植手技の工夫

    三浦 宏平, 佐原 寿史, 脇 詩織, 河合 昭浩, 清水 章, 山田 和彦

    日本外科学会雑誌115 ( 臨増2 ) 923 - 923   2014年3月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • GalT-KOブタ・霊長類間異種腎臓移植の拒絶反応におけるブタサイトメガロウィルス(pCMV)の関与

    脇 詩織, 佐原 寿史, 三浦 宏平, 河合 昭浩, 田崎 正行, 清水 章, 山田 和彦

    移植48 ( 総会臨時 ) 373 - 373   2013年8月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • MHC確立ミニブタ前臨床腎移植モデルを用いた温虚血障害腎に対する常温臓器保存の有効性の検討

    河合 昭浩, 佐原 寿史, 関島 光裕, 三浦 宏平, 脇 詩織, 清水 章, 山田 和彦

    移植48 ( 総会臨時 ) 327 - 327   2013年8月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • ドナー臓器修復に基づく新たな移植成績向上戦略のMHC確立クラウンミニブタ肺移植モデルによる評価と有用性

    佐原 寿史, 三浦 宏平, 河合 彰浩, 脇 詩織, 清水 章, 山田 和彦

    移植48 ( 総会臨時 ) 372 - 372   2013年8月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 脳死ドナーに対する一酸化炭素(CO)吸入によるMHC完全不適合クラウンミニブタ移植肺生着延長効果

    三浦 宏平, 佐原 寿史, 脇 詩織, 河合 昭浩, 清水 章, 山田 和彦

    移植48 ( 総会臨時 ) 372 - 372   2013年8月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 超過小グラフト血液型不適合生体肝移植術後に肝動脈血栓症発症した一例

    大矢 洋, 佐藤 好信, 小林 隆, 小海 秀央, 佐藤 優, 下田 傑, 三浦 宏平, 齋藤 敬太, 八木 亮磨, 若井 俊文

    日本消化器外科学会総会68回   P - 135   2013年7月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

  • 抗体関連型拒絶反応の克服に向けて 肝移植における既存抗体陽性例

    小林 隆, 大矢 洋, 佐藤 好信, 山本 智, 小海 秀央, 佐藤 優, 下田 傑, 三浦 宏平, 齋藤 敬太, 八木 亮磨, 畠山 勝義, 若井 俊文

    今日の移植26 ( 2 ) 182 - 187   2013年4月

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    記述言語:日本語   出版者・発行元:(株)日本医学館  

  • 臓器移植医療が一般外科にもたらすもの

    佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 畠山 勝義

    新潟医学会雑誌127 ( 2 ) 119 - 120   2013年2月

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    記述言語:日本語   出版者・発行元:新潟医学会  

  • 常温体外肺循環回路(EVLP)下での一酸化炭素吸入によるミニブタ移植肺への効果

    佐原 寿史, 脇 詩織, 関島 光裕, 三浦 宏平, 河合 昭浩, 清水 章, 山田 和彦

    今日の移植25 ( 6 ) 495 - 499   2012年11月

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    記述言語:日本語   出版者・発行元:(株)日本医学館  

  • High-mobility group box 1(HMGB1)が腎虚血再灌流障害(IRI)進展に及ぼす役割の大動物モデルによる解明

    三浦 宏平, 佐原 寿史, 関島 光裕, 河合 昭浩, 脇 詩織, 清水 章, 山田 和彦

    移植47 ( 総会臨時 ) 212 - 212   2012年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • High-mobility Group Box-1(HMGB1)を標的とする新たな肺虚血再灌流障害(IRI)抑制戦略の大動物モデルによる検討

    脇 詩織, 佐原 寿史, 関島 光裕, 三浦 宏平, 河合 昭浩, 清水 章, 山田 和彦

    移植47 ( 総会臨時 ) 244 - 244   2012年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • MHC確立ミニブタ前臨床腎移植モデルを用いた温虚血障害腎に対する常温臓器保存の有効性の検討

    河合 昭浩, 佐原 寿史, 関島 光裕, 三浦 宏平, 脇 詩織, 清水 章, 山田 和彦

    移植47 ( 総会臨時 ) 193 - 193   2012年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 敗血症を呈した亜急性型劇症肝炎に対する脳死肝移植の経験

    三浦 宏平, 佐藤 好信, 小海 秀央, 大矢 洋

    日本肝胆膵外科学会・学術集会プログラム・抄録集24回   491 - 491   2012年5月

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    記述言語:日本語   出版者・発行元:(一社)日本肝胆膵外科学会  

  • MELD scoreから見た肝移植周術期の免疫動態

    大矢 洋, 佐藤 好信, 山本 智, 原 義明, 小林 隆, 渡辺 隆興, 小海 秀央, 坂本 武也, 三浦 宏平, 畠山 勝義

    日本外科学会雑誌113 ( 臨増2 ) 401 - 401   2012年3月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 生体肝移植におけるSmall-for-size 病態の解明と対策 生体肝移植 過小グラフトにおける基礎と臨床

    佐藤 好信, 山本 智, 大矢 洋, 中塚 英樹, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 畠山 勝義

    日本外科学会雑誌113 ( 臨増2 ) 188 - 188   2012年3月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 次世代を目指す新しい手術手技(肝臓・胆道・膵臓) 同所性自家肝移植および異所性自家膵移植

    佐藤 好信, 山本 智, 大矢 洋, 小林 隆, 小海 秀央, 原 義明, 三浦 宏平, 畠山 勝義

    日本臨床外科学会雑誌72 ( 増刊 ) 350 - 350   2011年10月

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    記述言語:日本語   出版者・発行元:日本臨床外科学会  

  • サイトメガロウイルス感染症 肝移植におけるテーラーメードのサイトメガロウイルス感染症対策を目指して

    佐藤 好信, 山本 智, 大矢 洋, 小林 隆, 原 義明, 小海 英央, 三浦 宏平, 冨山 智香子, 谷口 委代, 畠山 勝義

    今日の移植24 ( 4 ) 391 - 396   2011年8月

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    記述言語:日本語   出版者・発行元:(株)日本医学館  

  • 生体肝移植後食道胃静脈瘤治療例の検討

    山本 智, 佐藤 好信, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 畠山 勝義

    移植45 ( 総会臨時 ) 217 - 217   2010年10月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 門脈圧亢進症と肝移植 肝移植と門脈圧亢進症 基礎と臨床

    佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 畠山 勝義

    日本門脈圧亢進症学会雑誌16 ( 2 ) 64 - 64   2010年8月

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    記述言語:日本語   出版者・発行元:(一社)日本門脈圧亢進症学会  

  • 食道胃静脈瘤再発症例に対するVaricos-Caval H-graftシャントの経験

    小海 秀央, 佐藤 好信, 山本 智, 大矢 洋, 小林 隆, 原 義明, 渡辺 隆興, 三浦 宏平, 畠山 勝義

    日本肝胆膵外科学会・学術集会プログラム・抄録集22回   406 - 406   2010年5月

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    記述言語:日本語   出版者・発行元:(一社)日本肝胆膵外科学会  

  • 肝移植における胆道・血行再建の工夫 Ligamentum teres hepatis間置Porto-cavalシャントによるnatural banding法の開発

    佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 畠山 勝義

    日本肝胆膵外科学会・学術集会プログラム・抄録集22回   208 - 208   2010年5月

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    記述言語:日本語   出版者・発行元:(一社)日本肝胆膵外科学会  

  • 成人生体肝移植 Ligament teres hepatisによるPorto-cavalシャントnatural banding法の開発

    佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 畠山 勝義

    日本外科学会雑誌111 ( 臨増2 ) 217 - 217   2010年3月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 成人生体肝移植における全肝温存異所性部分肝移植の可能性

    三浦 宏平, 佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 畠山 勝義

    日本外科学会雑誌111 ( 臨増2 ) 216 - 216   2010年3月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • GRWR<0.6%の超過小グラフトを用いた生体部分肝移植

    山本 智, 佐藤 好信, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 黒崎 功, 白井 良夫, 畠山 勝義

    日本外科学会雑誌111 ( 臨増2 ) 521 - 521   2010年3月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  • 劇症肝炎に対する治療戦略 劇症肝炎に対する生体肝移植の問題点と工夫

    佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 畠山 勝義

    日本腹部救急医学会雑誌30 ( 2 ) 275 - 275   2010年2月

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    記述言語:日本語   出版者・発行元:(一社)日本腹部救急医学会  

  • 9cm上腹部正中切開HALSによる左葉ドナー肝切除

    佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 小海 秀央, 三浦 宏平, 畠山 勝義

    日本内視鏡外科学会雑誌14 ( 7 ) 601 - 601   2009年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内視鏡外科学会  

  • 無症候性PBCと診断されたPBC生体肝移植ドナー候補の2例

    小海 秀央, 佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 渡辺 隆興, 三浦 宏平, 山際 訓, 野本 実, 畠山 勝義

    移植44 ( 総会臨時 ) 248 - 248   2009年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

  • 間質性肺炎を有する原因不明の肝硬変肝腎不全症例に対する全肝温存異所性部分肝移植の経験

    三浦 宏平, 佐藤 好信, 山本 智, 大矢 洋, 原 義明, 小林 隆, 渡辺 隆興, 小海 秀央, 畠山 勝義

    移植44 ( 総会臨時 ) 363 - 363   2009年9月

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    記述言語:日本語   出版者・発行元:(一社)日本移植学会  

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講演・口頭発表等

  • Development of the total pancreatectomy and autologous islet transplantation models as the step for allogenic islet transplantation experiments in the swine 国際会議

    三浦 宏平

    27th International Congress of The Transplantation Society  2018年7月2日 

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    記述言語:英語  

  • The roles of sphingosine-1-phosphate produced by sphingosine kinases in tumor and its microenvironment 国際会議

    三浦 宏平

    13th Annual Academic Surgical Congress  2018年2月 

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    記述言語:英語  

  • Dysregulation of sphingolipids in human hepatocellular carcinoma 国際会議

    三浦 宏平

    13th Annual Academic Surgical Congress  2018年2月 

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    記述言語:英語  

  • Adult living donor liver transplantation for patients with portal vein thrombosis. A single-center experience 国際会議

    三浦 宏平

    15th Congress of the Asian Society of Transplantation  2017年11月29日 

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    記述言語:英語  

  • Right posterior segment graft in adult living donor liver transplantation. A single-center experience 国際会議

    三浦 宏平

    18th Congress of the European Society for Organ Transplantation  2017年9月26日 

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    記述言語:英語  

  • Biliary anastomotic stricture after adult living donor liver transplantation. A single-center experience 国際会議

    三浦 宏平

    6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association  2017年6月8日 

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    記述言語:英語  

  • Auxiliary partial orthotopic liver transplantation versus heterotopic auxiliary partial liver transplantation – single center experience 国際会議

    三浦 宏平

    the 26th international congress of the transplantation society  2016年8月20日 

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    記述言語:英語  

  • Study of immune tolerance cases in adult living donor liver transplantation 国際会議

    三浦 宏平

    the 14th congress of asian society of transplantation  2015年8月26日 

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    記述言語:英語  

  • Development of the Intestinal transplantation model with MHC inbred CLAWN miniature swine 国際会議

    三浦 宏平

    the 14th congress of asian society of transplantation  2015年8月24日 

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    記述言語:英語  

  • Beneficial effects of inhaled carbon monoxide (CO) to brain-dead (BD) donors on prolonging pulmonary allograft survival in MHC-inbred CLAWN miniature swine 国際会議

    三浦 宏平

    The 13th Congress of the Asian Society of Transplantation  2013年9月4日 

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    記述言語:英語  

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